Comparative Efficacy of 1% Alendronate Gel and Tetracycline Fibers as an Adjunct to Scaling and Root Planing: a Randomized Control Clinical Trial

نویسندگان

  • Anjali Goel
  • Sachit Anand Arora
چکیده

The objective of this study was to compare efficacy of 1% Alendronate gel and Tetracycline fibers as an adjunct to scaling and root planning (SRP). A total of 30 patients with diagnosis of chronic periodontitis (60 localized periodontitis sites) in an age group of 20-55 years were selected. None of these patients had received any non-surgical or surgical periodontal therapy and had periodontal pockets measuring 4–7 mm clinically. Two sites in any quadrants after randomization were selected in each patient. Navy Plaque index (Grossaman and Fedi) and Gingival bleeding index (GI) (Loe and Sillness), Clinical probing depth (PD) and Clinical attachment level (CAL) were measured at baseline 1,3 and 6 months. Random allocation of test site (treated with 1% Alendronate Gel) and control site (treated with Tetracycline fibers). The results revealed that there was significant improvement in all clinical parameters from baseline to 6 months and test group presented with better results than control group however the difference was not statistically significant. INTRODUCTION: Periodontol disease is an inflammatory disease of the supporting tissues of teeth caused by an array of microorganisms, resulting in progressive destruction of periodontol ligament and alveolar bone with pocket formation, recession or both. 1 The host defense system aggravates production of cytokines and other mediators which progresses towards alveolar bone resorption and irreversible bone loss. 2-5 QUICK RESPONSE CODE DOI: 10.13040/IJPSR.0975-8232.7(10).4134-39 Article can be accessed online on: www.ijpsr.com DOI link: http://dx.doi.org/10.13040/IJPSR.0975-8232.7 (10).4134-39 Tetracycline has been used to treat periodontal disease due to its unique ability to reduce degeneration of collagenous matrix by inhibiting to reduce degradation of collagenous matrix by inhibiting the matrix metallo proteinases(MMP s) . 6 Golub et al 6 suggested that a systemic regimen of Subgingival Dose Doxycycline which reduced matrix metallo proteinases activity and alveolar bone resorption in patients with chronic periodontitis. Bisphosphonates are potent inhibitors of bone resorption, and osteoporosis. 7 Reddy et al 8 did a study on beagle dogs and results revealed that systemic administration of bisphosphonate was beneficial in preventing alveolar bone destruction in periodontal disease.

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تاریخ انتشار 2016